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What Is Sodium Pentobarbital?

Sodium pentobarbital also known by its brand name Nembutal is a short-acting barbiturate used as a sedative, hypnotic, and anticonvulsant. It works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces neuronal excitability throughout the nervous system. This results in calming, sleep-inducing, and seizure-controlling properties.

Originally developed in the early 20th century, pentobarbital sodium has been widely used in both human and veterinary medicine. Today, it remains one of the most trusted agents for euthanasia in animals and, in some jurisdictions, for physician-assisted dying in humans.

You can find more clinical background on pentobarbital’s pharmacology via DrugBank or review its chemical structure and safety profile through PubChem.

Chemical and Pharmacological Profile of Sodium Pentobarbital

Let’s break down the science behind this powerful compound without drowning you in jargon.

CAS Number

The Chemical Abstracts Service (CAS) registry number for sodium pentobarbital is 57-33-0. This unique identifier helps researchers, regulators, and suppliers track the compound across databases and international markets.

Molecular Formula & Weight

Molecular Formula: C₁₁H₁₇N₂NaO₃
Molecular Weight: 248.26 g/mol

This molecular configuration allows it to cross the blood-brain barrier quickly, which explains its rapid onset of action , typically within minutes when administered intravenously.

Mechanism of Action

Sodium pentobarbital binds to GABA-A receptors in the central nervous system. When bound, it prolongs the opening of chloride ion channels, increasing inhibitory neurotransmission. The result? Neurons fire less frequently, leading to:

Sedation
Hypnosis
Anticonvulsant effects
Respiratory depression (at higher doses)

This mechanism is well-documented in peer-reviewed journals such as those found on ScienceDirect and referenced in clinical guides like StatPearls.

Common Uses of Sodium Pentobarbital

While often associated with euthanasia, pentobarbital sodium serves multiple therapeutic purposes:

Use Case	Description
Veterinary Euthanasia	Most common application; humane termination of pets and livestock
Human Medical Use	Pre-anesthetic, emergency seizure control, short-term insomnia treatment
Research Applications	Used in neuroscience labs for inducing anesthesia in animal models
Physician-Assisted Dying	Legal in select countries/states under strict protocols

For detailed information on how pentobarbital is used in clinical settings, consult Memorial Sloan Kettering’s patient education materials or the VA Formulary Advisor.

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Side Effects and Risks You Should Know

Like all potent medications, sodium pentobarbital carries risks , especially if misused or taken without medical supervision.

Common Side Effects:

Drowsiness
Dizziness
Nausea
Slurred speech
Impaired coordination

Serious Side Effects (Require Immediate Medical Attention):

Breathing difficulties
Slow or irregular heartbeat
Severe drowsiness or unconsciousness
Allergic reactions (rash, swelling, difficulty breathing)

Overdose can lead to coma or death. According to MedlinePlus, symptoms of overdose include:

“Extreme drowsiness, confusion, slow or difficult breathing, weak pulse, cold and clammy skin, and loss of consciousness.”

If you suspect an overdose, seek emergency medical help immediately.

Legal Status Around the World

The legality of sodium pentobarbital varies significantly depending on your location. Here’s a quick overview:

United Kingdom

In the UK, pentobarbital is classified as a Class B controlled drug under the Misuse of Drugs Act 1971. Possession without a prescription is illegal. However, it may be legally obtained through private veterinary clinics or under specific palliative care programs.

United States

In the US, pentobarbital sodium is a Schedule II controlled substance, meaning it has accepted medical use but a high potential for abuse. It is primarily available through licensed veterinarians or hospitals. Some states allow its use for physician-assisted dying under strict regulations.

Germany

In Germany, natriumpentobarbital is regulated under the Narcotics Act (Betäubungsmittelgesetz). It requires a special prescription and is mostly restricted to veterinary use. Personal possession without authorization is prohibited.

Australia

Australia classifies pentobarbital as a Schedule 4 substance , available only with a prescription from a registered medical practitioner. Its use for euthanasia is permitted in certain states under the Voluntary Assisted Dying laws.

Asia

Regulations vary widely across Asian countries. In Japan, it is tightly controlled. In Thailand, it may be accessible through veterinary channels. Always check local laws before attempting to purchase.

For country-specific guidance, visit our regional pages:

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Dosage Guidelines for Sodium Pentobarbital

Dosage depends heavily on intended use, body weight, and route of administration. Never self-administer without consulting a healthcare professional.

For Humans (Medical Use Only):

Intramuscular Injection:

Adults: 150–200 mg as a single dose
Children: 2–6 mg/kg, not exceeding 100 mg per dose

Intravenous Injection:

Must be administered slowly (no faster than 50 mg/min)
Requires continuous monitoring of vital signs
Equipment for resuscitation must be available

For Animals (Veterinary Use):

Dosing varies by species and size. Common guidelines include:

Animal Type	Recommended Dose (mg/kg)
Dogs	30–50
Cats	30–60
Small Rodents	50–100

Always follow instructions provided by your veterinarian or refer to reputable sources like Mayo Clinic Labs for serum level testing and dosing accuracy.

Frequently Asked Questions About Sodium Pentobarbital

Can I buy sodium pentobarbital without a prescription?

In most countries, pentobarbital sodium is a prescription-only medication. However, in some regions, it may be legally purchased for veterinary or research purposes without a personal prescription. Always verify local laws before ordering.

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What is the street name for Nembutal?

Common street names include:

“Nem”
“Pent”
“Barbs”
“Yellow Jackets” (referring to capsule color)

These terms are sometimes used in illicit contexts, but we strongly advise against unauthorized use.

Learn more about slang terminology: What is the street name for Nembutal?

How long does sodium pentobarbital stay in your system?

Detection windows depend on the test type:

Test Type	Detection Window
Urine	Up to 7–21 days
Blood	Up to 24–48 hours
Hair	Up to 90 days

For forensic or employment screening, consult DrugBank or ScienceDirect for pharmacokinetic data.

Is Nembutal legal in France?

In France, pentobarbital sodique is strictly regulated under the French Public Health Code. It is generally reserved for veterinary use and cannot be legally obtained for human consumption without explicit authorization from a licensed physician.

Can I use Nembutal for my pet?

Yes , pentobarbital is the standard agent used in veterinary euthanasia due to its rapid, painless action. It is administered intravenously and causes unconsciousness within seconds, followed by cardiac arrest.

For guidance on safe usage: Where to buy pentobarbital for dogs | Compassionate Paths to Peaceful Farewells

Key Takeaways

Sodium pentobarbital is a powerful barbiturate used for sedation, seizure control, and euthanasia.
It acts by enhancing GABA activity in the brain, producing calming and sleep-inducing effects.
Available in multiple forms: powder, tablets, oral solution, injectable liquid.
Legality varies by country , always check local regulations before purchasing.
Overdose can be fatal; never self-administer without medical supervision.
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